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Discontinuing GLP-1 medications is a complex process that requires careful planning
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There may be risk of cardiac arrhythmias
This is achieved with a dosage that reduces appetite enough for gradual weight loss, but still keeps the patient's hunger and fullness signals
When patients are fully informed about the trade-offs, they are more likely to commit to consistent therapy
Semaglutide, tirzepatide, and retatrutide (Biosynth, Compton, UK, lot #s 0000042482, 0000054911, and 0000205204 respectively) were dissolved in 0.3% phosphate-buffered saline (PBS), which was adjusted to a pH of 8.0 using NaOH and injected subcutaneously (s.c.) at 1 ml/kg
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